April 22nd, 2011 by Dr.Helper

Buy Abilify (Aripiprazole) online

What do I need to know about Abilify?

• In clinical studies described accidental or intentional overdose of aripiprazole with a single intake to 1260 mg, not accompanied by death.
• The case of overdose of aripiprazole in children (reception to 195 mg). Potentially dangerous symptoms of overdose were extrapyramidal disorder, and transient loss of consciousness.
• When using antipsychotics, there have been cases of esophageal motility disorders and as a result, aspiration pneumonia. Precautions should be prescribed to patients with risk factors for aspiration pneumonia.
• Due to the risk of orthostatic hypotension Abilify should be used with caution in patients with cardiovascular disease (myocardial infarction, ischemic heart disease, heart failure, cardiac conduction disturbances in history), stroke, or states predisposing to hypotension (dehydration, hypovolemia , Therapy with antihypertensive drugs).
• After oral aripiprazole is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is reached after 3-5 h. The absolute bioavailability – 87%. Food intake did not affect the bioavailability of aripiprazole.

What is Abilify?

• Antipsychotic (neuroleptic).
• Aripiprazole is also characterized by a moderate affinity for serotonin reuptake sites and the lack of affinity for muscarinic receptors. In experimental animal studies, aripiprazole showed antagonism against dopaminergic hyperactivity and dopaminergic agonism against gipoaktivnosti. Some clinical effects of aripiprazole may be explained by interaction with dopamine and serotonin receptors.
• Abilify shown as a supplement to therapy with lithium or valproic acid for the treatment of manic or mixed episodes in the presence of psychotic symptoms, or without them;
• Abilify treating schizophrenia: acute episodes and maintenance therapy, bipolar disorder type I: manic episodes and maintenance therapy to prevent relapse in patients with bipolar disorder type I, has recently suffered a manic or mixed episode.

Abilify Pics

What do I need to discuss with my doctor before taking Abilify?

• There are no adequate and well-controlled clinical studies on the safety of pregnancy was carried out. Abilify can be used in pregnancy when the potential benefits of therapy to the mother justifies the potential risk to the fetus.
• We do not know whether to select a aripirazol with breast milk in humans. Not recommended for use during lactation (breastfeeding).
• Patients with hepatic insufficiency does not require dosage adjustment of the drug.
• Patients with renal failure require adjustment in dose.
• The propensity to suicidal thoughts and attempts is typical for patients with psychosis, bipolar disorder and major depressive disorder, so drug therapy must be coupled with careful medical supervision. Abilify should be prescribed in the minimum effective dose, it will reduce the risk of overdose.
• Do not use the drug Abilify in psychosis due to dementia and elderly patients with Alzheimer’s disease.
• As with other antipsychotics, the appointment Abilify patient should be warned about the dangers of working with moving machinery and driving.

Method of application

• When schizophrenia encouraged to nominate Abilify the initial dose of 10-15 mg 1 time per day. Regardless of the meal. Maintenance dose is 15 mg / day. In clinical studies, the effectiveness of the drug in doses ranging from 10 to 30 mg / day.
• When manic episodes in bipolar disorder as monotherapy, the recommended starting dose is 15 mg 1 time per day. Regardless of the meal. Changing the dose, if necessary, should be conducted at intervals of not less than 24 h. In clinical studies demonstrated efficacy at doses of 15-30 mg / day. at reception for 3-12 weeks. Safety of the drug in doses exceeding 30 mg / day. in clinical trials has not been evaluated.
• When monitoring patients with bipolar disorder type I manic or mixed episodes in which the observed stabilization of symptoms in patients receiving the drug Abilify for 6 weeks at a dose of 15 mg / day. or 30 mg / day. at an initial dose of 30 mg / day. and then – 6 months and then – for 17 months, set a favorable effect of such a maintenance therapy. You should periodically examine the patient to determine the need for continued maintenance therapy.
• As a complement to therapy with lithium or valproic acid, the recommended initial dose Abilify – 15 mg 1 time per day. Regardless of the meal. Depending on clinical indications dosage may be increased to 30 mg / day.
• In major depressive disorder as adjunctive therapy to treatment with antidepressants Abilify recommended to prescribe an initial dose of 5 mg / day. If necessary and well tolerated therapy daily dose Abilify can increase weekly by 5 mg up to maximum – no more than 15 mg / day.

What are the possible side effects of Abilify?

• Cardio-vascular system: often – orthostatic hypotension, tachycardia, and sometimes – bradycardia, palpitations, myocardial infarction, the lengthening of the interval QT, cardiac arrest, hemorrhage, atrial fibrillation, heart failure, AV-block, myocardial ischemia, deep vein thrombosis, phlebitis, premature beats.
• From the digestive system: Very common – nausea, loss of appetite, often – increased appetite (for the treatment of depression in combination with antidepressants), indigestion, vomiting, constipation, hypersecretion of saliva, dry mouth, heaviness in abdomen, diarrhea, and sometimes – gastroenteritis , difficulty swallowing, flatulence, gastritis, dental caries, gingivitis, hemorrhoids, gastroesophageal reflux, gastrointestinal hemorrhage, periodontal abscess, swelling of the tongue, fecal incontinence, colitis, rectal hemorrhage, stomatitis, ulceration of the oral mucosa, cholecystitis, fekaloma , candidiasis of the mucous membranes of the mouth, belching, stomach ulcers, rarely – esophagitis, bleeding gums, glossitis, hematemesis, intestinal bleeding, duodenal ulcer, cheilitis, increased liver, intestinal perforation, very rarely – increased activity of ALT, AST and ALP, hepatitis, jaundice, pancreatitis, dysphagia.
• On the part of the musculoskeletal system: often – arthralgia, muscle rigidity, and sometimes – myasthenia gravis, arthritis, arthrosis, muscle weakness, muscle cramps, bursitis, very rarely – increased activity of CPK, rhabdomyolysis, tendonitis, tenobursit, myalgia.
• part of the respiratory system: often – shortness of breath, pneumonia, and sometimes – epistaxis, hiccup, laryngitis, rarely – hemoptysis, increased sputum, dryness of the nasal mucosa, pulmonary edema, pulmonary embolism, hypoxia, respiratory failure, sleep apnea.
• On the part of the reproductive system: sometimes – amenorrhea, premature ejaculation, vaginal bleeding, vaginal candidiasis, uterine bleeding, menorrhagia, rarely – pain in the breast, cervicitis, galactorrhea, anorgasmia, burning in the area of the external genitalia, gynecomastia (breast enlargement in men), painful erection, very rarely – priapism.
• From the side of the body in general: often – asthenia, fatigue, flu-like syndrome, a sense of trembling in the body, sometimes – peripheral edema, facial edema, nausea, light sensitivity, jaw pain, chills, stiff jaw, tension in the chest, rarely – sore throat , stiffness in the back, heaviness in the head, candidiasis, stiffness in the neck, Mendelson syndrome, heat stroke, very rarely – a violation temperature regulation, fever, chest pain in the neck.